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Risk Factors for Fracture Events in Maintenance Hemodialysis Patients

Received: 18 January 2021    Accepted: 15 February 2021    Published: 26 February 2021
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Abstract

Objective: To explore risk factors for fracture events in maintenance hemodialysis patients. Methods: The study population was obtained from the hospital in patient database in China. There were 654 eligible patients with hemodialysis from 2018 – 2020. Other patient-related variables collected include gender, age, history of hypertension, history of diabetes mellitus, dialysis age, active vitamin D, hemoglobin, serum albumin, total cholesterol, triglyceride, serum corrected calcium. The primary outcome was any factors of fracture. Patients were followed until complete treatment or death. Besides, we performed subgroup analyses and used generalized linear models to assess interaction effects in logistic regressions. To clarify the relationship between fracture and risk factors, logistic regression was used. Result: By comparing non-fracture group and fracture group, we found that some factors were significantly difference, including gender, age, active vitamin D, and albumin (p = 0.001, p = 0.001, p < 0.001, p < 0.001). base on multivariate Logistic regression analysis of fracture occurrence in hemodialysis patients, older age, female, and low albumin were independent risk factors for fracture (p < 0.05). Also, the use of active vitamin D is a protective factor for fractures (p < 0.05). Conclusion: the risk factors for fracture events in maintenance hemodialysis patients included older age, female, low albumin, and active vitamin D.

Published in American Journal of Nursing Science (Volume 10, Issue 1)
DOI 10.11648/j.ajns.20211001.28
Page(s) 95-97
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Maintenance Hemodialysis, Fracture, Risk Factors

References
[1] McLeod K, Brodie MP, Fahey PP, Gray RA. Long-term survival of surgically treated hip fracture in an Australian regional hospital. Anaesth Intensive Care. 2017; 33: 749e55.
[2] Ramay BM, Cerón A, Méndez-Alburez LP, Lou-Meda R. Fac-tors associated to acceptable treatment adherence among children with chronic kidney disease in Guatemala. PLoSOne. 2017; 12, e0186644.
[3] Longenecker JC, Coresh J, Powe NR, et al. Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE Study. J Am Soc Nephrol. 2018; 13: 1918-1927.
[4] Shimoyama T, Kimura K, Shibazaki K, et al. Maintenance hemodialysis independently increases the risk of early death after acute intracerebral hemorrhage. Cerebrovasc Dis. 2017; 36: 47-54.
[5] Tentori F, McCullough K, Kilpatrick RD, et al. High rates of death and hospitalization follow bone fracture among hemodialysis patients [J]. Kidney Int. 2019, 85 (1): 166-173.
[6] Chang AJ, Ying Q, Chen XN, et al. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis. Osteoporos Int. 2016; 27 (12): 3599-3606.
[7] Zheng D, Sato S, Arima H, et al. Estimated GFR and the effect of intensive blood pressure lowering after acute intracerebral hemorrhage. Am J Kidney Dis. 2016; 68: 94-102.
[8] Laible M, Horstmann S, M€ohlenbruch M, et al. Renal dys-function is associated with deep cerebral microbleeds but not white matter hyperintensities in patients with acute intracerebral hemorrhage. J Neurol. 2015; 262: 2312-2322.
[9] Fulop T, Zsom L, Rodríguez RD, et al. Therapeutic hypernatremia management during continuous renal replacement therapy with elevated intracranial pressures and respiratory failure. Rev Endocr Metab Disord. 2019; 20: 65-75.
[10] Hung AM, Ellis CD, Shintani A, Booker C, Ikizler TA. IL-1beta receptor antagonist reduces inflammation in hemodialysis patients. J. Am. Soc. Nephrol. 2020; 22: 437–442.
[11] Zhou XL, Guo YD, Zhang CX, Tian Ru, Jia Meng, Luo Yang. Analysis of risk factors for fracture events in maintenance hemodialysis patients. Medical Review. 2021; (06): 1240-1243+1249.
[12] Chen HM, Liu FY, Zhou Y, Xiong D, Gong ZJ. Analysis of fracture incidence and risk factors in maintenance hemodialysis patients. Contemporary Medicine, 2020; 26 (16): 78-81.
[13] Molina P, Carrero JJ, Bover J, et al. Vitamin D, a modulator of musculoskeletal health in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2017; 8 (5): 686-701.
[14] Akagawa M, Miyakoshi N, Kasukawa Y, et al. Effects of activated vitamin D, alfacalcidol, and low-intensity aerobic exercise on osteopenia and muscle atrophy in type 2 diabetes mellitus model rats. PLoS One. 2018; 13 (10): e0204857.
[15] Rix M, Eskildsen P, Olgaard K. Effect of 18 months of treatment with alfacalcidol on bone in patients with mild to moderate chronic renal failure. Nephrol Dial Transplant. 2016; 19 (4): 870-876.
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  • APA Style

    Sijing Shao, Huixia Yu. (2021). Risk Factors for Fracture Events in Maintenance Hemodialysis Patients. American Journal of Nursing Science, 10(1), 95-97. https://doi.org/10.11648/j.ajns.20211001.28

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    ACS Style

    Sijing Shao; Huixia Yu. Risk Factors for Fracture Events in Maintenance Hemodialysis Patients. Am. J. Nurs. Sci. 2021, 10(1), 95-97. doi: 10.11648/j.ajns.20211001.28

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    AMA Style

    Sijing Shao, Huixia Yu. Risk Factors for Fracture Events in Maintenance Hemodialysis Patients. Am J Nurs Sci. 2021;10(1):95-97. doi: 10.11648/j.ajns.20211001.28

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  • @article{10.11648/j.ajns.20211001.28,
      author = {Sijing Shao and Huixia Yu},
      title = {Risk Factors for Fracture Events in Maintenance Hemodialysis Patients},
      journal = {American Journal of Nursing Science},
      volume = {10},
      number = {1},
      pages = {95-97},
      doi = {10.11648/j.ajns.20211001.28},
      url = {https://doi.org/10.11648/j.ajns.20211001.28},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20211001.28},
      abstract = {Objective: To explore risk factors for fracture events in maintenance hemodialysis patients. Methods: The study population was obtained from the hospital in patient database in China. There were 654 eligible patients with hemodialysis from 2018 – 2020. Other patient-related variables collected include gender, age, history of hypertension, history of diabetes mellitus, dialysis age, active vitamin D, hemoglobin, serum albumin, total cholesterol, triglyceride, serum corrected calcium. The primary outcome was any factors of fracture. Patients were followed until complete treatment or death. Besides, we performed subgroup analyses and used generalized linear models to assess interaction effects in logistic regressions. To clarify the relationship between fracture and risk factors, logistic regression was used. Result: By comparing non-fracture group and fracture group, we found that some factors were significantly difference, including gender, age, active vitamin D, and albumin (p = 0.001, p = 0.001, p < 0.001, p < 0.001). base on multivariate Logistic regression analysis of fracture occurrence in hemodialysis patients, older age, female, and low albumin were independent risk factors for fracture (p < 0.05). Also, the use of active vitamin D is a protective factor for fractures (p < 0.05). Conclusion: the risk factors for fracture events in maintenance hemodialysis patients included older age, female, low albumin, and active vitamin D.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Risk Factors for Fracture Events in Maintenance Hemodialysis Patients
    AU  - Sijing Shao
    AU  - Huixia Yu
    Y1  - 2021/02/26
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajns.20211001.28
    DO  - 10.11648/j.ajns.20211001.28
    T2  - American Journal of Nursing Science
    JF  - American Journal of Nursing Science
    JO  - American Journal of Nursing Science
    SP  - 95
    EP  - 97
    PB  - Science Publishing Group
    SN  - 2328-5753
    UR  - https://doi.org/10.11648/j.ajns.20211001.28
    AB  - Objective: To explore risk factors for fracture events in maintenance hemodialysis patients. Methods: The study population was obtained from the hospital in patient database in China. There were 654 eligible patients with hemodialysis from 2018 – 2020. Other patient-related variables collected include gender, age, history of hypertension, history of diabetes mellitus, dialysis age, active vitamin D, hemoglobin, serum albumin, total cholesterol, triglyceride, serum corrected calcium. The primary outcome was any factors of fracture. Patients were followed until complete treatment or death. Besides, we performed subgroup analyses and used generalized linear models to assess interaction effects in logistic regressions. To clarify the relationship between fracture and risk factors, logistic regression was used. Result: By comparing non-fracture group and fracture group, we found that some factors were significantly difference, including gender, age, active vitamin D, and albumin (p = 0.001, p = 0.001, p < 0.001, p < 0.001). base on multivariate Logistic regression analysis of fracture occurrence in hemodialysis patients, older age, female, and low albumin were independent risk factors for fracture (p < 0.05). Also, the use of active vitamin D is a protective factor for fractures (p < 0.05). Conclusion: the risk factors for fracture events in maintenance hemodialysis patients included older age, female, low albumin, and active vitamin D.
    VL  - 10
    IS  - 1
    ER  - 

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Author Information
  • Blood Purification Center, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Blood Purification Center, The First Affiliated Hospital of Jinan University, Guangzhou, China

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